St. John's Wort
St. John's wort is a plant with yellow flowers whose medicinal uses were first recorded in ancient Greece. The flowering tops of St. John's wort are used to prepare teas, tablets, and capsules containing concentrated extracts. Liquid extracts and topical preparations are also used. Today, St. John's wort is used by some for depression, anxiety, and/or sleep disorders.
For Consumers
- St. John's Wort and Depression
- St. John's Wort and Depression Clinical Trial Results
- St. John's Wort Interactions Warning (FDA)
- Using Dietary Supplements Wisely
Research Spotlights
- For Minor Depression, Study Shows No Benefit Over Placebo From St. John’s Wort, Citalopram (NIMH)
- A Review of St. John's Wort Extracts for Major Depression (October 2008)
- St. John's Wort Shows No Impact on the Symptoms of ADHD (June 2008)
- Study Shows St. John's Wort Ineffective for Major Depression of Moderate Severity (April 2002)
Ongoing Medical Studies
- Search for Active Medical Research Studies (ClinicalTrials.gov)
For Health Professionals
Clinical Practice Guidelines
- Clinical Use of Dietary Supplements and Nutraceuticals [1MB PDF] (Endocrine Practice)
- Herbs and Supplements in Managed Care (The Permanente Journal)
Continuing Education (CME, CEU)
Scientific Literature
- Systematic Reviews/Reviews/Meta-Analysis (PubMed® Citations)
- Randomized Controlled Trials (PubMed® Citations)
- Herb-Drug Interactions (PubMed® Citations)
* Note: PDF files require a viewer such as the free Adobe Reader.
